RAS: Striking at the Core of the Oncogenic Circuitry - PMC
Encoded by the KRAS4A, KRAS4B, HRAS, and NRAS genes, RAS family members are among the most frequently altered oncogenes in human cancers.
It took a long, long time: Ras and the race to cure cancer: Cell
Mar 28, 2024 · To begin, the discovery of the mutant ras oncogene in rodent and human tumors triggered an outpouring of analyses of human tumor genomes. Initially, there was the hope that RAS …
What is a RAS Mutation? | Dana-Farber Cancer Institute
Jan 6, 2025 · RAS — or rat sarcoma — is an oncogene, a gene that when mutated causes cancer. It is the most commonly mutated oncogene in human cancer.
Oncogene Ras - an overview | ScienceDirect Topics
Oncogene Ras refers to an important proto-oncogene, H-ras, K-ras, and N-ras, which plays a crucial role in regulating cell growth and transmitting mitogenic cell signaling from the cell surface to the …
RAS signaling in carcinogenesis, cancer therapy and resistance ...
Nov 9, 2024 · RAS was firstly identified as a virus-encoded gene by Jennifer Harvey and her colleagues in 1964 [1]. It was regarded as an oncogene, being one of the most frequently mutated genes in …
Oncogenic RAS in Cancers from the DNA Replication Stress and …
In this review, we systematically address and dwell on the details of the mechanisms of RAS oncogene-mediated alteration in the DNA replication and DNA damage response (DDR) pathways, focusing on …
RAS oncogenes: weaving a tumorigenic web - Nature
Oct 13, 2011 · RAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently...
Structure, signaling and the drug discovery of the Ras oncogene …
The Ras genes, which are proto-oncogenes that are mutated in human cancers, are encoded by three expressed genes: H-, K-, and N-Ras (13). Three Ras genes encode 188–89 residue proteins that …
Oncogene Ras - an overview | ScienceDirect Topics
Oncogene Ras refers to mutant forms of the ras genes that result in the constitutive activation of Ras proteins, contributing to tumorigenic phenotypes in cancer cells.
Ras oncogenes: split personalities - PMC
These findings extended the concept of multistep carcinogenesis and suggested that mutant Ras proteins can only transform (to a tumorigenic state) cells that have undergone predisposing changes.