MARCH1 negatively regulates TBK1-mTOR signaling pathway by ...
In response to growth factor stimulation, MARCH1 interacts with STING/TBK1 and promotes their ubiquitination. Subsequently, the ubiquitinated TBK1 decreases its interaction with mTOR and …
Ubiquitin-like protein 3 (UBL3) is required for MARCH ...
Apr 11, 2022 · UBL3 impacts ubiquitination of MARCH1 substrates, a mechanism that requires UBL3 plasma membrane anchoring via prenylation.
The E3 ubiquitin ligase MARCH1 regulates antimalaria ... - PNAS
Jun 30, 2020 · Therefore, MARCH1 may influence the expression of key proteins such as STING in IFN-I responses through direct ubiquitination for degradation and by altering the numbers of cell …
MARCH1 negatively regulates TBK1-mTOR signaling ... - Springer
Jul 26, 2024 · In response to growth factor stimulation, MARCH1 interacts with STING/TBK1 and promotes their ubiquitination. Subsequently, the ubiquitinated TBK1 decreases its interaction with …
Physiological substrates and ontogeny-specific expression of ...
Jan 1, 2021 · Confirmation that MAVS, STING, TRAF3 and TRAF6 are MARCH1 substrates will require direct assessment of their ubiquitination status in cells that do or do not express MARCH1.
MARCH1 promotes the ubiquitination of TBK1. A MARCH1 …
Download scientific diagram | MARCH1 promotes the ubiquitination of TBK1. A MARCH1 promoted the degradation of STING.
Regulation of MHC class II and CD86 expression by March-I in ...
Jun 1, 2023 · Surface expression of these proteins is regulated by their dynamic ubiquitination by the E3 ubiquitin ligase March-I. March-I promotes turnover of peptide–MHC-II complexes on resting APCs …